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Page 1
Did you mean test and disease models, Animal (76,062 results)?
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT, Bernstein BE. Griffin GK, et al. Nature. 2021 Jul;595(7866):309-314. doi: 10.1038/s41586-021-03520-4. Epub 2021 May 5. Nature. 2021. PMID: 33953401 Free PMC article.
Here, to identify factors that modulate the immune sensitivity of cancer cells, we performed in vivo CRISPR-Cas9 screens targeting 936 chromatin regulators in mouse tumour models treated with immune checkpoint blockade. We identified the H3K9 methyltransferase SETDB1 and o …
Here, to identify factors that modulate the immune sensitivity of cancer cells, we performed in vivo CRISPR-Cas9 screens targeting 936 chrom …
The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection.
Arieta CM, Xie YJ, Rothenberg DA, Diao H, Harjanto D, Meda S, Marquart K, Koenitzer B, Sciuto TE, Lobo A, Zuiani A, Krumm SA, Cadima Couto CI, Hein S, Heinen AP, Ziegenhals T, Liu-Lupo Y, Vogel AB, Srouji JR, Fesser S, Thanki K, Walzer K, Addona TA, Türeci Ö, Şahin U, Gaynor RB, Poran A. Arieta CM, et al. Cell. 2023 May 25;186(11):2392-2409.e21. doi: 10.1016/j.cell.2023.04.007. Epub 2023 Apr 13. Cell. 2023. PMID: 37164012 Free PMC article.
BNT162b4 elicits polyfunctional CD4(+) and CD8(+) T cell responses to diverse epitopes in animal models, alone or when co-administered with BNT162b2 while preserving spike-specific immunity. Importantly, we demonstrate that BNT162b4 protects hamsters from severe …
BNT162b4 elicits polyfunctional CD4(+) and CD8(+) T cell responses to diverse epitopes in animal models, alone or when co-admi …
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration.
Sorrentino G, Perino A, Yildiz E, El Alam G, Bou Sleiman M, Gioiello A, Pellicciari R, Schoonjans K. Sorrentino G, et al. Gastroenterology. 2020 Sep;159(3):956-968.e8. doi: 10.1053/j.gastro.2020.05.067. Epub 2020 May 30. Gastroenterology. 2020. PMID: 32485177 Free article.
We induced colitis in Tgr5(ISC-/-) mice by administration of dextran sulfate sodium; disease severity was determined based on body weight, colon length, and histopathology analysis of colon biopsies. ...
We induced colitis in Tgr5(ISC-/-) mice by administration of dextran sulfate sodium; disease severity was determined based on body we …
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. Katsyuba E, et al. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356218 Free PMC article.
Using animal models to improve the design and application of transcranial electrical stimulation in humans.
Sánchez-León CA, Ammann C, Medina JF, Márquez-Ruiz J. Sánchez-León CA, et al. Curr Behav Neurosci Rep. 2018 Jun;5(2):125-135. doi: 10.1007/s40473-018-0149-6. Epub 2018 Apr 25. Curr Behav Neurosci Rep. 2018. PMID: 30013890 Free PMC article.
Here, we review studies that have taken advantage of animal models to provide invaluable insight about the basic science behind tES. ...SUMMARY: Animal models provide a wealth of information that can facilitate the successful utilization of t
Here, we review studies that have taken advantage of animal models to provide invaluable insight about the basic science behin …
Pathogenesis of Collagen-Induced Arthritis: Role of Immune Cells with Associated Cytokines and Antibodies, Comparison with Rheumatoid Arthritis.
Šteigerová M, Šíma M, Slanař O. Šteigerová M, et al. Folia Biol (Praha). 2023;69(2):41-49. doi: 10.14712/fb2023069020041. Folia Biol (Praha). 2023. PMID: 38063000 Free article. Review.
Rheumatoid arthritis is a systemic inflammatory and autoimmune disease affecting joints, accompanied by significant extra-articular symptoms. ...We discuss the crucial roles of various immune cells (subtypes of T and B lymphocytes, dendritic cells, monocytes, macrophages), …
Rheumatoid arthritis is a systemic inflammatory and autoimmune disease affecting joints, accompanied by significant extra-articular s …
Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models.
Yu WS, Aquili L, Wong KH, Lo ACY, Chan LLH, Chan YS, Lim LW. Yu WS, et al. Ann N Y Acad Sci. 2022 Sep;1515(1):249-265. doi: 10.1111/nyas.14850. Epub 2022 Jun 25. Ann N Y Acad Sci. 2022. PMID: 35751874
In this study, we investigated the effects of transcorneal electrical stimulation (TES) on memory enhancement using two mouse models, in aged mice and in the 5XFAD model of Alzheimer's disease. ...Overall, these findings support further investigation of TE
In this study, we investigated the effects of transcorneal electrical stimulation (TES) on memory enhancement using two mouse mode
Role of testosterone and androgen receptor in periodontal disease progression in female rats.
Steffens JP, Valenga HM, Santana LCL, Albaricci MCDC, Kantarci A, Spolidorio LC. Steffens JP, et al. J Periodontol. 2020 Apr;91(4):545-553. doi: 10.1002/JPER.19-0099. Epub 2019 Aug 25. J Periodontol. 2020. PMID: 31389012
Herein, we investigated the role of androgen receptor and TES on the inflammatory response and alveolar bone resorption associated with ligature-induced periodontal disease in female rats. METHODS: Fifty female Holtzman rats were divided in five groups (n = 10/group …
Herein, we investigated the role of androgen receptor and TES on the inflammatory response and alveolar bone resorption associated wi …
Antidepressant-like effects of transcorneal electrical stimulation in rat models.
Yu WS, Tse AC, Guan L, Chiu JLY, Tan SZK, Khairuddin S, Agadagba SK, Lo ACY, Fung ML, Chan YS, Chan LLH, Lim LW. Yu WS, et al. Brain Stimul. 2022 May-Jun;15(3):843-856. doi: 10.1016/j.brs.2022.05.018. Epub 2022 May 28. Brain Stimul. 2022. PMID: 35640844 Free article.
METHODS: TES was administered daily for 1 week in S334ter-line-3 and CUS rats. ...Treatment with the neurogenesis blocker temozolomide only inhibited the hedonic-like effect of TES, suggesting the antidepressant-like effects of TES were mediated through both …
METHODS: TES was administered daily for 1 week in S334ter-line-3 and CUS rats. ...Treatment with the neurogenesis blocker temozolomid …
Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review.
Stocco E, Barbon S, Mammana M, Zambello G, Contran M, Parnigotto PP, Macchi V, Conconi MT, Rea F, De Caro R, Porzionato A. Stocco E, et al. J Tissue Eng. 2023 Feb 27;14:20417314231151826. doi: 10.1177/20417314231151826. eCollection 2023 Jan-Dec. J Tissue Eng. 2023. PMID: 36874984 Free PMC article. Review.
Revising the literature, many Authors report about different methods for acellular tracheal ECMs development; however, only few of them verified the devices effectiveness by an orthotopic implant in animal models of disease. To support translational medicine …
Revising the literature, many Authors report about different methods for acellular tracheal ECMs development; however, only few of them veri …
100 results